Notezilla remembers notes positions for every display resolution. If you are seeing notes positions being synced then it is possible that both home & office PCs have same display resolution although they have different multiple monitor setup.
So you have to make sure the resolutions are not the same. Maybe change the display resolution manually. If you set a different display resolution on both PCs then you will achieve what you want. The notes positions will be remembered separately.
Also, if accidentally the display resolution changes, you can configure Notezilla to work in the way you want. You can do this in the General Tab of the Preferences Menu.